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Friday January 11,2008

The New Jersey of the East
By Rob Fannon, editor, Phase 1 Investor
January 11, 2008

The man who made the world's best selling drug just got canned.

So much for loyalty at Pfizer – the world's largest drug company. Rather than showering Dr. Bob Sliskovic with gratitude for his work on Lipitor, which has generated $80 billion in sales, the pharmaceutical giant just handed the 23-year lab veteran a pink slip.

Sliskovic is one of 2,100 employees fired from Pfizer's 177-acre research and development campus in Ann Arbor, Michigan. The company shut down operations on the heels of a five-year, $300 million expansion plan. The closing is part of new CEO Jeff Kindler's strategy for a radical makeover at Pfizer. When the shift is all said and done, Kindler expects to save $2 billion with some 10,000 fewer employees on the company's payroll.

Lipitor netted $13 billion last year. Yet, along with several other top-selling traditional drugs, Lipitor is racing headfirst off a patent cliff. In 2007, generic copycats erased $16 billion worth of brand-name drug sales. By 2010, the projected figures soar well north of $100 billion. So Pfizer's wise to start pinching pennies now.

Big Pharma's big moneysaving secret is that at least one-third of its research and development work isn't performed in-house – it's outsourced.

Of the $45 billion biotech and drug companies spent on R&D last year, 33% was outsourced. That number is slated to surpass 40% of research budgets by 2009. As domestic research budgets grow by 5%-6% a year, reserves earmarked for outsourced R&D continue to shoot up 15%-17% annually.

And where is that spending headed? Consider this...

On average, R&D work in India or China costs 40% less than here in the U.S.

Not surprisingly, research spending in China and India surpassed $2.2 billion in 2006, twice as much as the year before. Both countries offer educated workforces, diverse populations for clinical studies, and cheap labor.

If you were the CEO of XYZ Drug Company, where would you choose to build your next manufacturing plant, conduct your next massive clinical trial, or carry out your drug-discovery work?

New Jersey is home to half of the world's top pharmaceutical companies. Without a doubt, the Garden State hosts the highest percentage of big drug money per capita.

Pfizer's $3 Billion Mistake
Why CROs Are the Safest Way to Profit from Drug Discovery

Right now, with billions of research dollars flowing abroad, China and India are fighting to gain similar status on the international level.

I've run out of space today, so I can't cover the details... But in Monday's edition, I'll tell you which country is set to emerge as the "New Jersey of the East" and the best ways to invest.

Until then... good investing,

Rob Fannon

$1,000 Gold Rocks China
The strong debut yesterday for the Shanghai gold futures market boosted the price of spot bullion to a fresh record high as investors anticipate a wave of Chinese investment in the precious metal.

Gold prices have been on a record-breaking run in recent months, as investors seek refuge from weakness in the dollar and concerns about the health of the global financial system. The price of spot bullion has gone up 40 per cent since January 2007. Read on...

Lennar Calls Bottom in Housing
Lennar Corp.'s November sale of 11,000 properties in eight states set a price that may mark the bottom for the U.S. housing market: 40 cents on the dollar.

That's how much Morgan Stanley Real Estate paid for an 80 percent stake in the 32 communities, 60 percent less than the price at which the properties were valued just two months earlier. That's also what some investors say they would pay for distressed land, condominiums, homes and whole developments, whether it's now or later this year. Read on...

 


Health care's quiet bull market continues... China Medical, Xenoport, Elan Covidien, C.R. Bard, and Covance hit new highs.

America's unstoppable credit collapse... New lows for American Express, Capital One, Discover, and Equifax.

Retail's reverse in full swing... Jos. A Bank, Barnes & Noble, AnnTaylor, and Bebe at 52-week lows.

Last Change 52-Wk
S&P 500 1419.11 0.71% 0.30%
Oil (USO) 74.05 -1.59% 63.54%
Gold (GLD) 80.49 2.09% 28.74%
Silver (SLV) 160.10 3.16% 29.39%
US Dollar 75.95 -0.53% -10.60%
Euro 1.479 0.73% 14.10%
VIX 24.12 -5.15% 102.52%
HUI 458.46 0.96% 46.57%
10-year yield 3.79% -0.05 -0.87

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