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How to Sell What Big Pharma Will Pay Any Price to Buy
By Dr. George Huang, editor, The S&A FDA Report

April 18, 2008

The Japanese have gone on a shopping spree.

In the last six months, two of Japan's biggest drugmakers in have scooped up two midsized U.S. biotech firms at nothing short of whopping valuations. This international binge bodes well for us biotech investors...

Last week, the biggest Japanese pharmaceutical company – Takeda Pharmaceuticals – shook the biotech world, paying close to $9 billion to acquire Millennium Pharmaceuticals. The multibillion-dollar price tag represented a 53% premium to Millennium's previous closing price. Even more startling, Takeda's outlay translates to 15 times Millennium's projected sales this year. (Most good midsized biotech companies sell for seven to nine times sales.) 

The Takeda-Millennium deal comes on the heels of another Japanese biotech buyout at the end of last year. Japan's fourth-largest drug company – Eisai – picked up U.S.-based MGI Pharma for 10 times sales. Apparently, MGI had multiple suitors. It's safe to assume that Eisai was willing to cough up enough cash to win out.

Both the Millennium and MGI Pharma buyouts highlight the point my colleague Rob Fannon and I have been making repeatedly: Biotech investors are right where they want to be because large drug companies are desperate to acquire biotech assets.

These companies face no other choice with expiring patents, empty pipelines, and tons of cash. The massive premiums on these two Japanese deals prove that certain companies are willing to pay any price to get their hands on biotech drugs.

Heck, there's even consolidation within the biopharma space. New Jersey-based Celgene, a leading cancer biotech company, acquired fellow biotech Pharmion last November for $3 billion, a 46% premium.

Three Ways to Get Rich in the Market's Most Volatile Sector

Biotech Is Setting Up for Another 1,347% Rally

So what does it mean for investors? The pool of midsized to large biotech companies with real revenues is rapidly shrinking. With so many mid-cap biotech companies being bought out, even the Wall Street Journal speculates this particular biotech segment may be a lucrative oasis during volatile times.

Here's how you can get in ahead of the windfall: Search for biotechs with existing or near-term product revenue, a rich pipeline, and an experienced management team. I prefer companies with revenue of at least $200 million or companies with potential blockbusters (sales of $1 billion or more) in Phase III testing. The pipeline should hold at least two drugs in early stage clinical trials. Lastly, management should have experience developing and selling drugs, with emphasis on their track record in dealings with the FDA.

Right now, many biotech companies with market caps between $1 billion and $5 billion fit the description. Start your search there.

Good investing,

George Huang

Student Lending Is "Broken"
SLM Corp., the largest U.S. student lender, recorded its third consecutive quarterly loss as gains from selling loans to investors dried up. The company said its new loans are unprofitable.

SLM, known as Sallie Mae, didn't have any first-quarter gains from arranging securities backed by student loans, compared with a $367.3 million infusion the year before. So-called core earnings by the Reston, Virginia-based company missed analysts' estimates. Read on...

Art Dealers Prepare for a Bust
If, like most entrepreneurs, you've been focused on the real estate recession and record-setting energy prices, you might not have noticed a big surprise in the art market: It's still partying like it's 1999.

At Sotheby's contemporary-art auction last fall, Jeff Koons's nine-foot-tall, 3,500-pound, vivid-pink stainless-steel sculpture "Hanging Heart" became the most expensive work by a living artist ever sold at auction, fetching $23.6 million. Two dozen artists saw their work achieve record-high prices that month as Sotheby's and Christie's booked sales of $1.7 billion, a 24% increase over the previous year's November sales. And in February a charity auction organized by rocker-activist Bono netted $42.6 million, comfortably ahead of Sotheby's $29 million estimate. Read on...


IBM nearly doubles profit... hits six-year high.

World's largest oil shipper Frontline at new high.

Retail still in trouble... American Eagle, Big Dog Holdings, Retail Ventures, Eddie Bauer, and Payless at new lows.
Earnings today... Caterpillar, Citigroup, Schlumberger.
Last Change 52-Wk
S&P 500 1378.78 0.51% -4.87%
Oil (USO) 80.11 1.74% 57.39%
Gold (GLD) 93.75 1.09% 37.67%
Silver (SLV) 186.44 3.64% 26.84%
US Dollar 74.80 -1.06% 10.86%
Euro 1.497 0.98% 13.61%
VIX 21.88 -4.99% 96.23%
HUI 477.79 2.45% 32.05%
10-year yield 3.86% -0.04 -0.77
Company Sym Industry

IBM

IBM

computers

Nucor

NUE

steel

Patterson-UTI

PTEN

oil drilling

International Coal

ICO

coal

Occidental Petroleum

OXY

oil & gas

U.S. Oil

USO

oil

Pride International

PDE

oil drilling

McMoRan Exp

MMR

oil & gas

Netflix

NFLX

movie rentals

Exelon

EXC

utilities

Frontline

FRO

shipping

Orbital Sciences

ORB

aerospace

Cleveland-Cliffs

CLF

iron ore

Valmont

VMI

metal fab

Permian Basin

PBT

oil & gas

Sasol

SSL

refining

TNS

TNS

networks

Buckle

BKE

clothing

Clayton Williams

CWEI

oil & gas

Forest Oil

FST

oil & gas

Hanesbrands

HBI

underwear

ABN AMRO

ABN

bank

Nabors

NBR

oil drilling

Stone Energy

SGY

oil & gas

Valhi

VHI

holding company

Weatherford

WFT

oil services

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Company Sym Industry

Harley-Davidson

HOG

motorcycles

Briggs & Stratton

BGG

engines

Novartis

NVS

Big Pharma

Retail Ventures

RVI

retail

Pinnacle Airlines

PNCL

airline

Align

ALGN

medical equip

Housevalues

SOLD

home sales

American Eagle

AEO

clothing

Big Dog Holdings

BDOG

clothes

Eddie Bauer

EBHI

clothing

Redhook

HOOK

beer

Las Vegas Sands

LVS

casinos

Lee Enterprises

LEE

newspapers

Pacific Ethanol

PEIX

ethanol

Payless

PSS

shoes

Great Wolf

WOLF

casinos

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