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Friday November 2 , 2007

Pfizer's $3 Billion Mistake
Rob Fannon, editor, The Medical Investor

When a world-class marketing machine like Pfizer can't sell a drug, that's when you know Big Pharma is in a world of hurt…

Last year, Pfizer spent $7.5 billion in research and development, a huge number for sure. Yet, it spent twice as much on marketing! That's right, more than $15 billion on a legion of blond bombshells to push its top-sellers like Lipitor and Viagra...

I've written extensively on Big Pharma's plight when it comes to generic drugs. Quite simply, drugmakers are scrambling to replace the more than 30% of revenues that will come under attack from generic copycats in the next two to three years.

Last December, Pfizer suffered a huge blow when it was forced to pull its top heart drug candidate due to "an imbalance of mortality and cardiovascular events" – meaning it actually induced deaths from heart attacks in clinical trials.

To add to its misery, the company announced two weeks ago that it was pulling yet another blockbuster-to-be off the market. But this time, it wasn't because of safety problems. The problem was the company couldn't sell the darn drug, even with its multibillion-dollar marketing budget.

The drug, called Exubera, was the first inhaled version of insulin on the market. The FDA approved it to treat diabetes back in October 2006. Yet, the company only managed to sell $12 million worth of the stuff so far this year. On the In the Pipeline daily blog, Derek Lowe, a drug discovery scientist, calls the sales "horrifyingly tiny... which can be rounded off to zero."

Pfizer finally threw in the towel and pulled Exubera off the market, at a cost of $3 billion charged against earnings.

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To anyone who knows anything about the drug industry, Pfizer is in big trouble. The company's forecasts for both the side effect-prone heart drug and underperforming Exubera were well north of $2 billion per year. Pfizer hoped to stuff these new drugs in its sales bags in order to replace the $10+ billion it will lose in revenues when its patent on the world's top-selling drug, Lipitor, expires in 2011.

With these two drugs now in the medical graveyard, there's absolutely no way the company will be able to replace these expiring sales.

At a $170 billion market cap, I wouldn't consider touching Pfizer stock until it shed at least 40%-50% of its value, something I think will happen in three to four years' time. When it does, a lot of folks are going to be unhappy when they open their retirement-fund statements. Pfizer is one of the most widely held stocks on the market. Fund managers just park money there, thinking the company will always be able to push its drugs to doctors and patients, a theory that was never disproved until the Exubera debacle.

I think Dr. Lowe nailed the company's near-term future prospects:

"Pfizer's situation remind[s] me of a slow-motion film of a train running toward a cliff... a colleague of mine said 'Yeah, me too, but in this case they're still boarding passengers and loading their luggage'."

My advice is to clean Pfizer out of your retirement portfolio and save yourself the sticker shock in a few years…

Good investing,

Rob Fannon
Editor, The Medical Investor

P.S. I cruise over to Dr. Lowe's blog, In the Pipeline, once a week. Derek is an organist chemist working in drug discovery. His insider perspective always makes for interesting and valuable reading. Check it out for yourself here.

P.P.S. Granted, most Big Pharma companies have problems right now, but there's one giant drug maker that's poised to benefit from nearly every problem facing its weaker competition. It's one of my top recommendations right now, and I recommend holding it for decades. For more on this drug giant and my favorite health care retirement plan, click here.

Wal-Mart Drops to New Low: $200 Computers
Scattered among the $500 to $1,000 desktop computers available at Walmart.com, one machine stands out. It doesn't have a unique design, but its price tag looks like a typo: $199.

Prices for consumer electronics goods, ranging from HDTVs to mobile phones, drop consistently, but few products have more potential to impact a person's ability to learn or find work than a computer.

The cheap computers – sold beginning this week at 20 Illinois Wal-Mart locations – are offered at a time when charitable efforts such as the "One laptop per child" program intended to provide portable computers for $100 to children in developing countries, have struggled to achieve results. That laptop will now cost $200, but the program has yet to deliver a product. Read on…

Oil-Rich Arabs Splurge on Local Art
Christie's International sold $15 million of contemporary works mainly by Arab and Iranian artists in Dubai last night, with records set for Middle East artists.

The sale at the Jumeirah Emirates Towers Hotel, Christie's third in the Persian Gulf emirate, produced an auction record for an Arab work of art when Ahmed Mustapha's "Qu'ranic Polyptych of Nine Panels" sold for $657,000. Mustapha held the previous record of $284,800, set at Christie's first Dubai auction in May 2006. (All prices for last night's sale include commission.)
Read on…


Big Banking in serious trouble... Washington Mutual, Citigroup, Bank of America, Wachovia, and Wells Fargo at yearly lows.

Oil touches $96... service firms GlobalSantaFe, Dril-Quip, Transocean, and Willbros Group hit fresh highs.

Medical stocks ignore bad earnings... Barr Pharmaceuticals, Express Scripts, MedcoHealth, HemoSense, and Dade Behring at new highs.

Last Change 52-Wk
S&P 500 1508.44 -2.64% 10.28%
Oil (USO) 72.17 -1.50% 38.47%
Gold (GLD) 77.97 -0.83% 27.07%
Silver (SLV) 140.48 -2.17% 12.89%
US Dollar 76.70 0.09% -10.27%
Euro 1.444 -0.17% 13.22%
VIX 18.53 -12.06% 66.94%
HUI 435.08 3.79% 36.46%
10-year yield 4.48% 0.09 -0.13
Company Sym Industry

MasterCard

MA

credit cards

Rick's Cabaret

RICK

strip clubs

Microsoft

MSFT

software

Aon

AOC

insurance

Google

GOOG

search engine

Makita

MKTAY

tools

Brit American Tob

BTI

cigarettes

GlobalSantaFe

GSF

oil drilling

Sohu

SOHU

online products

Assurant

AIZ

insurance

Express Scripts

ESRX

pharma services

Bally

BYI

gaming machines

Dynamic Materials

BOOM

niche metals

Oilsands Quest

BQI

oil exploration

HemoSense

HEM

medical equip

Unilever

UL

conglomerate

Dril-Quip

DRQ

oil services

Baidu

BIDU

search engine

Intel

INTC

semiconductors

Capella Education

CPLA

education

Dade Behring

DADE

diagnostics

Barr Pharma

BRL

pharma

Miramar

MNG

gold

Public Service Ent

PEG

utilities

MedcoHealth

MHS

pharma services

Transocean

RIG

oil drilling

United Thera

UTHR

biotech

Southwestern En

SWN

oil & gas

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Company Sym Industry

CBS

CBS

media

Ruth's Chris

RUTH

steakhouses

U.S. Concrete

RMIX

cement

Asbury Auto

ABG

auto dealer

Coachmen

COA

RVs

Bank of America

BAC

bank

Owens Corning

OC

building mat

Autobytel

ABTL

online auto

Miller Industries

MLR

auto parts

CB Richard Ellis

CBG

real estate

Fremont General

FMG

mortgages

Cali Pizza Kitchen

CPKI

restaurants

Arctic Cat

ACAT

ATVs

Scott's Miracle

SMG

lawn care

Washington Mu

WM

bank

Citigroup

C

bank

Morton's

MRT

steakhouses

CompuCredit

CCRT

credit services

Brookfield Homes

BHS

homebuilder

CarMax

KMX

auto dealer

West Marine

WMAR

boats

MBIA

MBI

credit insurance

Columbia

COLM

athletic apparel

FTD Group

FTD

flowers

Brinker Intl

EAT

restaurants

Wachovia

WB

bank

Journal Comm

JRN

newspapers

Centex

CTX

homebuilder

Monaco Coach

MNC

RVs

Perry Ellis

PERY

clothing

Sprint Nextel

S

telecom

McCormick & Sch

MSSR

restaurants

Stein Mart

SMRT

discount retail

Wells Fargo

WFC

bank

Sun Times Media

SVN

newspaper

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